Interdisciplinary Laboratory of Molecular Biology and Biophysics
kierownik zespołu:
Edward Darżynkiewicz

Współpracownicy

mgr Maja Cieplak
doktorantka, Wydz. Fizyki
dr Renata Grzela
mgr Anna Kropiwnicka
doktorantka, MISDoMP
mgr Dorota Kubacka
doktorantka, Wydz. Fizyki
mgr Beata Miedziak
dr Magdalena Murawska
mgr Magdalena Rudzińska
mgr Agnieszka Stelmachowska
prac. inżynieryjno-techniczny, Wydz. Fizyki
mgr Michał Tyras
mgr Małgorzata Zarębska
doktorantka, Wydz. Fizyki
dr Joanna Żuberek
adiunkt, Wydz. Fizyki
dr Maciej Łukaszewicz
adiunkt, Wydz. Fizyki

O laboratorium

The Laboratory’s main field of interest covers the structures of the so-called cap, i.e. the 5’ end of mRNAs and many snRNAs. Cap analogs synthesized in the past by us, including the natural trimethylguanosine cap and cap-4, significantly contributed to the discovery of the biological role of these structures.

Currently our activity is focused on interdisciplinary studies on the molecular mechanisms of interactions between cap structures and protein regulator factors that are involved  in processes of protein biosynthesis and intracellular mRNA transport.

Within a wider scope mRNA metabolism the research on biosynthesis and degradation of cap structures by capping and decapping enzymes is currently being carried on. Attempts are made to combine basic research with practical applications such as by designing and synthesis of mRNA transcripts stable and translationally highly active in a cell, that can be used for biotechnological protein production and development of anti-cancer vaccines. In our research we use a broad range of chemical, biological and biophysical methodologies. Our team cooperates with several specialist laboratories located both in Poland and abroad.

Współpraca krajowa:
  • Prof. Jan Antosiewicz, Faculty of Physics University of Warsaw
  • Prof. Janusz Bujnicki, The International Institute of Molecular and Cell Biology, Warsaw
  • Krzysztof Ginalski, PhD, CeNT University of Warsaw
  • Marzena Jankowska-Anyszka, PhD, DSc, Faculty of Chemistry University of Warsaw
  • Jacek Jemielity, PhD, DSc, CeNT University of Warsaw
  • Prof. Joanna Kufel, Faculty of Biology University of Warsaw
  • Anna Niedźwiecka, PhD, Institute of Physics Polish Academy of Sciences, Warsaw
  • Prof. Ryszard Stolarski, Faculty of Physics University of Warsaw
  • Prof. Zbigniew Wieczorek, Faculty of Physics and Biophysics, University of Warmia and Mazury, Olsztyn

 

Współpraca zagraniczna:
  • Prof. David A. Campbell, University of California at Los Angeles, USA
  • Prof. Richard E. Davis, University of Colorado, Aurora, USA
  • Prof. John Gross, University of California, San Francisco, USA
  • Prof. Robert E. Rhoads, Louisiana State University, Shreveport, USA
  • Prof. Ugur Sahin, Johannes-Gutenberg University, Mainz, Germany
  • Prof. Michal Shapira, Ben-Gurion University of the Negev, Beer Sheva, Israel
  • Prof. Edvard Smith, Karolinska Institute, Stockholm, Sweden
  • Prof. Nahum Sonenberg, McGill University, Montreal, Canada
  • Prof. Nancy Standart, Cambridge University, Cambridge, United Kingdom

 

News

Tuesday, May 19, 2015 - 09:45

The ceremony took place on May 15 at the Palace of Culture and Science in Warsaw. Prof. Edward Darżynkiewicz is the head of the Interdisciplinary Laboratory of Molecular...