Laboratory of Bioorganic Chemistry
kierownik zespołu:
Jacek Jemielity

Team

Marek Baranowski
student, Wydz. Fizyki
Sylwia Bednarek
studentka, Wydz. Fizyki
mgr inż. Sebastian Chmieliński
Jakub Dąbrowski
student, Wydz. Fizyki
mgr Kaja Fac
doktorantka, MISDoMP
Renata Kasprzyk
studentka, Wydz. Fizyki, Wydz. Chemii
dr Natalia Kleczewska
mgr Michał Kopciał
doktorant, MISDoMP
dr Joanna Kowalska
adiunkt, Wydz. Fizyki
Mateusz Kozarski
student, Wydz. Fizyki
Andrzej Kraszewski
student, MISMaP
dr Dorota Kubacka
adiunkt, Wydz. Fizyki
Maciej Majewski
student, Wydz. Fizyki, Wydz. Chemii
Mieszko Majka
student, MISMaP
Adam Mamot
student, MISMaP
Monika Nowakowska
studentka, Wydz. Chemii
mgr Anna Nowicka
doktorantka, Wydz. Fizyki, Wydz. Chemii
Radosław Piwowarski
student, Wydz. Chemii
Aleksandra Pompa
studentka, MISMaP
dr Tomasz Ratajczak
dr inż. Paweł Sikorski
mgr Malwina Strenkowska
doktorantka, Wydz. Fizyki
mgr Dominika Strzelecka
doktorantka, Wydz. Chemii
mgr Sylwia Walczak
doktorantka, MISDoMP
mgr Przemysław Wanat
doktorant, Wydz. Fizyki
mgr Zofia Warmińska
doktorantka, MISDoMP
mgr Marcin Warmiński
doktorant, Wydz. Fizyki
mgr Małgorzata Waszczuk
doktorantka, Wydz. Fizyki
mgr Katarzyna Wnęk
Wydz. Fizyki
dr inż. Błażej Wojtczak
Paulina Wysmołek
studentka, Wydz. Fizyki
dr Marcin Ziemniak

O laboratorium

Laboratory of Bioorganic Chemistry is focused on the synthesis, properties and applications of modified nucleotides (including analogs of mRNA 5’ cap, nucleoside triphosphates, nucleotide sugars, nucleoside phosphosulfates and many others). The main goal of our research is to create tools useful for elucidating biological processes involving nucleotides and to find new potential nucleotide-derived therapeutics.

To do so, we develop new synthetic methods for the chemical and enzymatic synthesis of nucleotides and their analogs. We are particularly interested in the synthesis and properties of nucleotides modified within the phosphate moieties. We design nucleotide analogs that increase cellular stability of mRNA and nucleotide-derived inhibitors of protein biosynthesis with increased stability under cellular conditions. We synthesize fluorescently labeled nucleotides, nucleotides with affinity tags as well as nucleotide-probes for NMR and EPR experiments. We also prepare and evaluate conjugates of nucleotides with nano(bio)materials.

The laboratory operates in two locations - team uses the hospitality of the Department of Biophysics, Faculty of Physics, University of Warsaw.

Współpraca krajowa:
  • Prof. Edward Darzynkiewicz, Faculty of Physics, University of Warsaw
  • Prof. Joanna Kufel, Faculty of Biology, University of Warsaw
  • Maciej Mazur, PhD, DSc, Faculty of Chemistry, University of Warsaw
Współpraca zagraniczna:
  • Prof. John Gross, University of California, San Francisco, USA
  • Prof. Robert E. Rhoads, Louisiana State University, Shreveport, USA
  • Prof. Ugur Sahin, University of Mainz, Germany
  • Prof. Roger Stromberg, Karolinska Institute, Stockholm, Sweden

News

Tuesday, December 20, 2016 - 10:45

Prof. Jacek Jemielity and prof. Krzysztof Ginalski got financing for TEAM projects in the amount of 3 500 000 PLN each.

The TEAM programme gives...
Friday, December 2, 2016 - 15:29

Adam Mamot, MISMaP student, member of the Laboratory of Bioorganic Chemistry, took the second place in the prestigious Golden Medal of Chemistry competition organized...

Wednesday, May 18, 2016 - 10:41

On May 16th, Marcin Ziemniak, the member of the Laboratory of Bioorganic Chemistry, headed by Jacek Jemielity, obtained on the Faculty of Physics University of Warsaw PhD...

Monday, December 21, 2015 - 14:50

On December 10 Malwina Strenkowska, MSc, the member of the LChB Team,...

Thursday, December 17, 2015 - 10:14

Wojciech Adamczyk, Piotr Orłowski, members of LTNMF team, and Maciej Majewski, memeber of LChB (Faculty of Physics University of Warsaw), have been awarded scholarships founded...