Laboratory of Human Cancer Genetics
kierownik zespołu:
Krystian Jażdżewski

O laboratorium

The aim of the projects implemented at the Laboratory of Human Cancer Genetics is to identify molecular changes underlying heritability and pathogenesis of human malignancies. Using the most innovative methods of molecular and genetic analysis, including next-generation sequencing, we seek for mutations that predispose to carcinogenesis.

We also analyze the function of regulatory RNAs, such as microRNAs, and the role of their disturbed expression or sequence in development and progression of cancer. We moreover aim to elucidate non-invasive molecular panels, based on measurements of microRNA expression in blood that will allow for diagnostics and prognostics of human cancers. Such panels might serve as a basis for personalized medicine. The Laboratory of Human Cancer Genetics is an interdisciplinary team, including medical doctors, molecular biologists, geneticists and bioinformaticians.

Recent papers:

  • Lakshmanan A, Wojcicka AKotlarek M, Zhang X, Jazdzewski K, Jhiang SM, MicroRNA-339-5p modulates Na+/I- symporter-mediated radioiodide uptake, Endocr Relat Cancer 2015, 22(1):11-21
  • Wojcicka A, Swierniak M, Kornasiewicz O, Gierlikowski W, Maciag M, Kolanowska M, Kotlarek M, Gornicka B, Koperski L, Niewinski G, Krawczyk M, Jazdzewski K. Next generation sequencing reveals microRNA isoforms in liver cirrhosis and hepatocellular carcinoma. Int J Biochem Cell Biol 2014; 53:208-17
  • Wojcicka A, Czetwertynska M, Swierniak M, Długosinska J, Maciag M, Czajka A, Dymecka K, Kubiak A, Kot A, Ploski R, de la Chapelle A, Jazdzewski K. Variants in the ATM-CHEK2-BRCA1 axis determine genetic predisposition and clinical presentation of papillary thyroid carcinoma. Genes Chromosomes Cancer 2014; 53(6):516-23
  • Wojcicka A, de la Chapelle A, Jazdzewski K. MicroRNA-related sequence variations in human cancers. Hum Genetics 2014; 133(4):463-9
Współpraca krajowa:
  • Prof. Barbara Górnicka, MD, PhD, Department of Pathology, Medical University of Warsaw
  • Prof. Piotr Stępień, PhD, Institute of Genetics and Biotechnology, Univeristy of Warsaw
  • Prof.  Dorota  Słowińska-Klencka, I Department of Endocrinology, Medical University of Lodz
Współpraca zagraniczna:
  • Prof. Albert de la Chapelle, MD,PhD, Comprehensive Cancer Center, The Ohio State University, USA
  • Prof. Sissy Jhiang, PhD, College of Medicine, The Ohio State University, USA
  • Prof. Stefano Volinia, Universita di Ferrara, Italy

News

Thursday, April 6, 2017 - 14:54

Prof. Krystian Jażdżewski, the head of the Laboratory of Human Cancer Genetics, is nominated in the category of Vision and Innovation for developing the most advanced...

Thursday, March 31, 2016 - 12:14
A team of Polish scientists, including CeNT’s researchers: Dr. Michał Świerniak, Dr. Anna Wójcicka, and Prof. Krystian Jażdżewski has discovered a method for more effective...
Thursday, December 17, 2015 - 11:01

Foundation Promotional Emblem "Teraz Polska" has chosen the president of Warsaw Genomics, Anna Wójcicka, PhD DSc, from the Laboratory of Human Cancer Genetics, CeNT, among 11...

Wednesday, November 18, 2015 - 13:55

On November 18 Anna Kubiak, the member of the Laboratory of Human Cancer Genetics obtained a PhD degree in medical science, specialization: medical biology. Ph.D. was conducted...

Friday, July 3, 2015 - 12:04

The Foundation for Polish Science announced the results of the 4th contest organized within the IMPULS program. 

There are two laureates from CeNT...