The research interest includes development of new theoretical and experimental tools and their application to investigate structure, function and evolution of proteins and their interaction with ligands. Research is also focused on application of next generation sequencing to a wide range of genomic, metagenomic and transcriptomic studies.
The group explores synthesis and physicochemical propertis of new chemical compounds – both in the solid state (‘extended’ i.e. 1D, 2D, 3D) and molecular (‘0D’). Combinations of diverse chemical elements together with broad (p,T) range offer rich diversity of structures and properties of stoichiometries appearing in the phase diagrams. We focus on electric, magnetic, thermal, and other properties, as well as chemical reactivity.
The research conducted in our group is devoted to the study of the interactions of semiconducting materials and metallic nanostructures with light. The investigations focus principally on photo-electrochemical properties of thin-layer semiconducting oxide electrodes, such as tungsten trioxide (WO3) or ferric oxide (Fe2O3) that are employed to split water or decompose contaminants present in water.
Work is focused on development of new tools for multidimensional spectroscopy based on novel signal processing. The laboratory provides equipment for NMR of proteins, solid state materials and suspensions.
Brain activity is based on propagation of electrical impulses along the axons of nerve cells and synaptic transmission. Neurons connect with one another to form electrical circuits, which are further grouped into systems that finally make a neural network. One of the systems is the thalamocortical complex - the center of perception and a regulator of the attention and awareness levels. Improper functioning of the thalamo-cortico-thalamic loop may result in some psychotic and affective disorders.
Laboratory of Bioorganic Chemistry is focused on the synthesis, properties and applications of modified nucleotides (including analogs of mRNA 5’ cap, nucleoside triphosphates, nucleotide sugars, nucleoside phosphosulfates and many others). The main goal of our research is to create tools useful for elucidating biological processes involving nucleotides and to find new potential nucleotide-derived therapeutics.
The aim of LSSCB (Chemical and Biological Systems Simulation Lab) is to develop and apply theoretical and computational methods (ranging from quantum chemistry to molecular mechanics/dynamics) to describe chemical, physical and biological phenomena. Particular focus of the lab is on prediction of protein structures, nanotechnology, homogeneous catalysis and physical organic chemistry.
The aim of the projects implemented at the Laboratory of Human Cancer Genetics is to identify molecular changes underlying heritability and pathogenesis of human malignancies. Using the most innovative methods of molecular and genetic analysis, including next-generation sequencing, we seek for mutations that predispose to carcinogenesis.
The research work conducted in our laboratory concerns metal alkoxides used as catalysts for the polymerization of heterocyclic monomers. Our interests focus on metal alkoxides, based on the group 13 and 14 metals, - catalysts for the polymerization of cyclic esters, which allow for the synthesis of biodegradable polyesters.
Neuronal plasticity is the ability of neurons to adapt permanent changes in response to environmental stimuli. This unique property of the nervous system underlies learning and memory formation.
The Laboratory’s main field of interest covers the structures of the so-called cap, i.e. the 5’ end of mRNAs and many snRNAs. Cap analogs synthesized in the past by us, including the natural trimethylguanosine cap and cap-4, significantly contributed to the discovery of the biological role of these structures.
The work in my lab is interested in the biological functions of RNA; we will use the spliceosome as a model, focusing on the study of molecular mechanisms that govern pre-mRNA splicing. Our goal is to understand the complex set of substrate-spliceosome interactions during assembly and catalysis that affect positioning of the reactive groups at the active site.
The aim of the projects carried out in the Laboratory of Experimental Medicine is to identify and validate novel molecular targets for anti-cancer therapies with the main focus on mechanisms regulating protein homeostasis in mammalian cells (such as ubiquitin-proteasome system, autophagy, endoplasmic reticulum-associated degradation, and unfolded protein response).
The sun powers almost all life on earth via the fundamental process of photosynthesis. The natural photosystems (photosystems I and II) capable of solar light capture and solar energy conversion are macromolecular membrane proteins holding pigments and cofactors together to create biological nanoscale solar energy converters operating at quantum efficiencies close to unity. Solar energy conversion is one of the few renewable ways to produce clean energy to meet the increasing demands of modern civilization.
In the Laboratory of Functional and Structural Genomics we perform theoretical studies, whose main objective is to analyze and predict the three-dimensional structure of the human genome, and its relation with the genomic diversity of human populations, both natural and pathological. In particular, we investigate structural variants, copy number variants observed in various sub-populations and the groups of patients, and their three-dimensional localization in the structure of the nucleus.
Communication between cells is an essential feature of living organisms. Signals received from the environment are processed and integrated by the cell, leading to changes in its morphology and behavior. Many human diseases, such as developmental defects and cancer, are caused by defective signal transduction.
Laboratory of Material Technologies is a shared initiative of two scientific centres: Centre of New Technologies (Warsaw University) and the Institute of Electronic Materials Technology (ITME). Laboratory is working closely with the Laboratory of Functional Materials situated in ITME. Prof. D. A. Pawlak is the leader of both laboratories which specialise in developing new material technologies and in obtaining novel materials applicable in photonics, optoelectronics, photoelectrochemistry and potentially in photovoltaics and medicine.
The research in our laboratory is aimed at the development of new methodologies for synthetic organic chemistry. The central focus of the investigations is directed toward the use of efficient chiral catalysts that can deliver products in high enantiopurities, which is a prerequisite for the present-day pharmaceutical applications. Our work spans over three major areas: asymmetric organocatalysis, organometallic chemistry, and computational chemical modelling.
The studies performed in the Laboratory of Crystal Engineering focus on the solid state and the rational modification thereof. They oscillate on the border of a few divisions of chemistry such as organic, coordination and supramolecular chemistry, material science and crystallography. They aim to expand the knowledge concerning the design of crystals of particular composition and properties.
Unveiling fundamental biological processes in adult stem cells regulation is important, since stem cells are not only required for physiological tissue or organ self-renewal but also play critical role during their regeneration after injury. Therefore understanding a precise regulation of adult stem cells homeostasis is very crucial since deregulation of stem cells self-renewal might result in organ failure or tumor formation.
The lab studies environment through analyses of satellite data and their integration with models of biological, physical and chemical processes. Our interests concern various spatial scales: from the whole Earth system to individual agricultural fields.
Currently we are working on these projects:
We are interested in the proteins and the process of their evolution. Our research is driven by the observation that known protein structures occupy only a very limited area in the virtually unlimited conformational space. The main project focuses on the highly regular and repetitive protein motifs and aims at the designing such new structures that have not been observed in nature. In our work, we employ computational biology techniques allowing for the precise analyses and simulations of the protein structures and sequences.
The research conducted in the laboratory is focused on the new materials which can be used for storage of energy. The two groups of materials are particularly explored, namely the hydrogen-rich compounds – potential chemical stores of hydrogen, and the novel ionic conductors – prospective safe and efficient electrolytes for application in electrochemical batteries.
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Mitochondria play an important role in metabolism and regulatory processes in the cell. Thus, the formation of mitochondria is essential for cellular function in the entire eukaryotic kingdom, from unicellular organisms to mammals. Mitochondria comprise 1000-1500 cellular proteins, which are synthesized outside of the mitochondria in the cytosol.
Genetic Analyzes for Environmental Protection Team deals with conservation genetics. This is the area combining population genetics , molecular ecology and...